High Purity 2-Chloro-3-Methylpyridine CAS 18368-76-8 Liquid Fine Chemical Raw Material for Organic Synthesis

Product Description

1. Product Overview
2-Chloro-3-methylpyridine (also named 2-Chloro-3-picoline, CAS 18368-76-8) is a colorless to light-yellow transparent chlorinated pyridine liquid, with a chlorine atom at the 2-position and a methyl group at the 3-position of the pyridine ring. It is stable under sealed inert-gas protection at room temperature, miscible with common organic solvents such as methanol, ethanol, chloroform and ether, and widely applied as a high-value chlorinated heterocyclic building block with active nucleophilic-substitution sites for organic synthesis.
This product is a core agro-pharmaceutical fine-chemical intermediate, mainly used as the key precursor for manufacturing neonicotinoid insecticides (imidacloprid, acetamiprid), herbicides (nicosulfuron, fluazifop) and pharmaceutical APIs (Lumacaftor, NSAIDs and anti-HIV drug candidates). Our factory supplies two mainstream grades: industrial standard grade (98.0% min GC purity) and high-purity premium grade (99.0% min GC, ultra-low trace chloropyridine homolog impurity). We maintain continuous bulk spot stock to support global dangerous-goods export, and each shipment is attached with official COA analysis certificate and GHS-standard SDS for customs clearance and overseas factory quality inspection.

2. Core Technical Specifications

Test Item	Industrial Standard Grade	High-Purity Premium Grade
CAS Number	18368-76-8	18368-76-8
Chemical Name	2-Chloro-3-methylpyridine	2-Chloro-3-methylpyridine
Synonym	2-Chloro-3-picoline	2-Chloro-3-picoline
Purity Content (GC)	>=98.0%	>=99.0%
Moisture Content	<=0.15%	<=0.08%
Chroma (APHA)	<=50	<=20
Pyridine-series Homolog Impurity	<=1.20%	<=0.40%
Melting Point	-45 C	-45 C
Boiling Point	192-193 C	192-193 C
Density (25 C, g/cm3)	1.165-1.175	1.167-1.173
Refractive Index (n20/D)	1.5310-1.5350	1.5320-1.5340
Flash Point	79 C	79 C
pKa (25 C)	0.75	0.75
Molecular Formula	c6h6cln	c6h6cln
Molecular Weight	127.57	127.57
Appearance	Colorless to light-yellow transparent flowing liquid	Water-white to pale-yellow crystal clear liquid
EINECS No.	242-242-1	242-242-1
HS Code	2933399090	2933399090

3. Export Transportation Packaging
We provide multiple UN-certified dangerous-goods packaging solutions matching different order volumes and application industries, all lined with chemical-resistant inner liner to prevent liquid leakage and air-contact degradation during long-distance sea transportation; all packages are equipped with complete dangerous-goods packaging certificate for maritime customs declaration:

1. 25kg UN HDPE Plastic Drum (Lab & Small Trial Pack)
   Sealed plastic barrel with nitrogen filling, exclusive for high-purity lab trial orders and fine-chemical customers. Each barrel attached independent COA & SDS, suitable for small-batch sample testing.

1. 200L UN Galvanized Sealed Steel Drum (Industrial Standard Bulk Pack)
   Closed-head UN-certified dangerous-goods iron drum, cost-effective for mass agro-pharmaceutical intermediate manufacturers, single drum net weight about 220kg, mainstream bulk export specification.

1. 1000L UN Composite IBC Tank (Full Container Large Wholesale Pack)
   1000L intermediate bulk container with drain valve and nitrogen sealing, the optimal package for full-container dangerous-goods shipment, greatly reducing unit packaging cost, suitable for long-term large-volume cooperative agro-chemical raw-material factories.

• Packaging Customization Support: Custom printed outer labels with customer brand logo, batch number, destination port dangerous-goods marking; nitrogen filling service for ultra-high-purity premium-grade batches.

• Compliance Guarantee: All containers pass IMDG dangerous-goods packaging inspection, full set of dangerous-goods transport appraisal and packaging certificate provided for global port customs clearance.

4. Wide Application Fields
4.1 Agrochemical Intermediate Manufacturing
Key chloropyridine intermediate for synthesis of high-efficiency neonicotinoid insecticides including imidacloprid and acetamiprid, which act as insect neurotoxins targeting crop pest nervous systems. Also a critical precursor for sulfonylurea herbicide nicosulfuron and aryloxyphenoxypropionate herbicide fluazifop. The reactive C-Cl bond at the 2-position supports nucleophilic substitution reaction to build pyridine-containing pesticide molecular structures, widely purchased by agro-chemical manufacturers in Southeast Asia, Europe and Latin America.
4.2 Pharmaceutical & Bio-active Molecule Synthesis
Important chlorinated heterocyclic building block for pharmaceutical R&D. Used as a key intermediate in the synthesis of cystic-fibrosis drug Lumacaftor, non-steroidal anti-inflammatory drugs (NSAIDs), and structurally related intermediates for anti-HIV drug nevirapine analogs. The 2-chloro and 3-methyl substitution pattern supports aromatic-ring derivatization to improve target-binding affinity and metabolic stability of drug molecules, applied in custom-synthesis and pharmaceutical-pilot-scale production workshops.
4.3 Fine-Chemical & Custom Organic Synthesis
Core raw-material for custom chlorinated heterocyclic derivatives. Supports various nucleophilic aromatic substitution reactions, Grignard-reagent formation for C-C bond construction, and transition-metal-catalyzed cross-coupling reactions, applied in custom-chemical factories for new-compound development and process-scale-up projects.
4.4 Laboratory Synthetic Reagent
Special chloropyridine reagent for organic-chemistry labs; widely used in heterocyclic-chemistry research, medicinal-chemistry exploration, coordination-chemistry ligand synthesis and analytical-chemistry derivatization experiments.

5. Factory & Export Advantages

1. Stable Automated Production & Spot Supply
   We own professional chloropyridine synthesis & high-vacuum rectification production workshop and 6,000-ton nitrogen-sealed dangerous-goods storage warehouse, guarantee 7-day fast delivery for full DG container orders, effectively avoid shipment-delay risk in peak-demand seasons.

1. Dual-Grade Strict Quality Control System
   Independent full-function laboratory equipped with gas chromatograph, trace-moisture tester, refractive-index detector and HPLC. Every batch undergoes full-index inspection before delivery, separate COA report issued for each batch to ensure stable purity and low-impurity fluctuation, no discoloration or liquid stratification under sealed storage.

1. Complete Global Dangerous-Goods Export Qualifications
   Free provision of full-set export-clearance documents: COA, GHS English SDS, commercial invoice, packing list, certificate of origin, IMDG dangerous-goods transport appraisal, UN packing certificate, support customs clearance for ports of Europe, America, Southeast Asia, Middle East and Latin America. Our product complies with TSCA, REACH, IECSC and global major chemical-registration standards.

1. Flexible Tiered Dangerous-Goods Quotation Policy

• Preferential bulk unit price for full 20GP / 40HQ dangerous-goods containers;

• Extra discount for 100% T/T advance payment;

• Annual-framework-agreement price-lock policy for long-term fixed purchasers to hedge raw-material-price-fluctuation losses.

1. Professional One-Stop DG Export Service
   Specialized dangerous-goods foreign-trade team handles DG trailer, hazardous-goods customs declaration, maritime dangerous-goods booking and full-logistics tracking; customers only need to wait for cargo arrival at destination port without complicated dangerous-goods formalities.

6. Storage, Transportation & Safety Instructions

1. Storage: Store in dedicated cool, dry, ventilated dangerous-chemical warehouse, strictly keep away from open flame, high-temperature heat source, strong oxidants and strong acids; container must be fully sealed with nitrogen filling to prevent air-contact degradation, storage temperature controlled below 30 C, shelf life 12 months under intact sealed package.

1. Transportation: Flammable organic-chemical liquid, must ship with professional IMDG dangerous-goods container, complete UN-packing certificate and DG-shipping document; avoid direct sunlight and violent collision during loading & unloading, strictly separate from oxidizer cargo.

1. Safety Operation: Operators must wear chemical-resistant gloves, anti-corrosion goggles and organic-vapor respirator; if liquid contacts skin or eyes, rinse with massive clean water continuously for 15 minutes and seek medical treatment immediately; avoid inhalation of vapor and prolonged skin contact. Full-English SDS details all fire-fighting, leakage-disposal and emergency-first-aid measures for overseas-warehouse management.

7. After-Sales Cooperation Guarantee

1. Batch Quality Traceability: We reserve sealed samples of each production batch for 6 months, support third-party independent re-inspection if customers raise quality doubts after goods arrival.

1. Quality-Problem Solution Mechanism: If test indexes fail to meet agreed standard, we support free re-delivery, proportional price deduction or economic compensation according to actual customer loss.

1. Long-Term Cooperative Client Priority Policy: Annual-framework customers enjoy priority-production scheduling, free lab-sample supply and one-to-one fine-chemical engineer technical-matching support.

1. Free Professional Technical Support: Our chloropyridine engineer team provides lifelong free technical consultation on 2-Chloro-3-methylpyridine dosing proportion, moisture-proof & air-isolation storage method and downstream nucleophilic-substitution synthesis-process optimization for all cooperative customers.