High Purity 3-Cyanopyridine CAS 100-54-9 ≥99% Gc Nicotinonitrile Organic Synthesis Intermediate for Vitamin B3 Derivatives

Product Description

1. Product Overview
3-Cyanopyridine (also named Nicotinonitrile, Pyridine-3-carbonitrile, CAS 100-54-9) is a white to pale-yellow crystalline solid with a pyridine ring bearing a nitrile group at the 3-position. It is readily soluble in water (140 g/L at 20 C), ethanol, ether, benzene and chloroform, stable under sealed room-temperature storage, and widely applied as a high-value nitrogen-containing heterocyclic building block with active nitrile reactivity for organic synthesis.
This product is a core pharmaceutical and agrochemical fine-chemical intermediate, mainly used as the primary industrial precursor for manufacturing nicotinic acid (Niacin, Vitamin B3) and nicotinamide (Niacinamide), as well as peripheral vasodilator nicotinyl alcohol, antihypertensive APIs and novel targeted-therapy drug candidates. Our factory supplies two mainstream grades: industrial standard grade (98.0% min GC purity) and high-purity premium grade (99.0% min GC, ultra-low trace pyridine-homolog impurity). We maintain continuous bulk spot stock to support global export, and each shipment is attached with official COA analysis certificate and GHS-standard SDS for customs clearance and overseas factory quality inspection.

2. Core Technical Specifications

Test Item	Industrial Standard Grade	High-Purity Premium Grade
CAS Number	100-54-9	100-54-9
Chemical Name	3-Cyanopyridine	3-Cyanopyridine
Synonym	Nicotinonitrile, Pyridine-3-carbonitrile	Nicotinonitrile, Pyridine-3-carbonitrile
Purity Content (GC)	>=98.0%	>=99.0%
Moisture Content	<=0.30%	<=0.15%
Melting Point	47-52 C	48-51 C
Boiling Point	201 C	201 C
Density (25 C, g/cm3)	1.155-1.163	1.157-1.161
Flash Point	84 C	84 C
Refractive Index (estimate)	1.5230-1.5260	1.5235-1.5255
Water Solubility (20 C)	>=135 g/L	>=138 g/L
Pyridine-series Homolog Impurity	<=1.20%	<=0.40%
Residue on Ignition	<=0.10%	<=0.05%
Molecular Formula	c6h4n2	c6h4n2
Molecular Weight	104.11	104.11
Appearance	White to pale-yellow crystalline powder or chunks	White crystalline powder, no visible impurities
EINECS No.	202-863-0	202-863-0
HS Code	2933399090	2933399090

3. Export Transportation Packaging
We provide multiple export-standard packaging solutions matching different order volumes and application industries, all lined with moisture-proof inner bag to prevent powder caking and moisture absorption during long-distance sea transportation; all packages are equipped with complete export packaging certificate for maritime customs declaration:

1. 25kg UN Fiber Drum (Lab & Small Trial Pack)
   Sealed composite fiber drum with polyethylene inner liner and nitrogen filling, exclusive for high-purity lab trial orders and fine-chemical customers. Each drum attached independent COA & SDS, suitable for small-batch sample testing.

1. 50kg Cardboard Drum (Industrial Standard Bulk Pack)
   Heavy-duty export cardboard drum with food-grade PE inner bag, cost-effective for mass vitamin and pharmaceutical intermediate manufacturers, single drum net weight 50kg, mainstream bulk export specification.

1. 500kg / 1000kg Jumbo Bag (Full Container Large Wholesale Pack)
   UV-stabilized polypropylene woven bulk bag with moisture-proof inner liner and discharge spout, the optimal package for full-container shipment, greatly reducing unit packaging cost, suitable for long-term large-volume cooperative vitamin raw-material factories.

• Packaging Customization Support: Custom printed outer labels with customer brand logo, batch number, destination port marking; vacuum or nitrogen filling service for ultra-high-purity premium-grade batches.

• Compliance Guarantee: All containers pass export packaging inspection, full set of transport appraisal and packaging certificate provided for global port customs clearance.

4. Wide Application Fields
4.1 Vitamin B3 (Niacin / Niacinamide) Manufacturing
The primary industrial precursor for synthesis of nicotinic acid (Niacin, Vitamin B3) and nicotinamide (Niacinamide). Through hydrolysis of the 3-position nitrile group, 3-Cyanopyridine is converted into the essential B-vitamin active ingredients with antipellagra activity, widely purchased by nutritional-supplement and feed-additive manufacturers in Europe, North America and Southeast Asia.
4.2 Pharmaceutical & Bio-active Molecule Synthesis
Important nitrile-functionalized heterocyclic building block for pharmaceutical R&D. Used as a key starting material for producing peripheral vasodilator nicotinyl alcohol, antihypertensive APIs, novel anticancer agents and kinase-inhibitor targeted-therapy candidates. The pyridine-ring scaffold and reactive nitrile group support multi-step derivatization to improve metabolic stability and target-binding affinity of drug molecules, applied in custom-synthesis and pharmaceutical-pilot-scale production workshops.
4.3 Agrochemical Intermediate Manufacturing
Key pyridine intermediate for synthesis of specialized pesticides and herbicides. The reactive nitrile group supports addition and condensation reactions to build pyridine-containing crop-protection molecular structures, widely used in agro-chemical factories for new-insecticide and herbicide development projects.
4.4 Coordination Chemistry & Fine-Chemical Synthesis
3-Cyanopyridine can act as a bridging or terminal ligand in transition-metal coordination polymers and metal-organic frameworks (MOFs). It is also a core raw material for custom nitrile-containing heterocyclic derivatives, supporting various nucleophilic addition, condensation and catalytic hydrogenation reactions, applied in custom-chemical factories for new-compound development and process-scale-up projects.
4.5 Laboratory Synthetic Reagent
Special nitrile-functionalized pyridine reagent for organic-chemistry labs; widely used in heterocyclic-chemistry research, medicinal-chemistry exploration, coordination-chemistry studies and analytical-chemistry derivatization experiments.

5. Factory & Export Advantages

1. Stable Automated Production & Spot Supply
   We own professional pyridine-derivative synthesis & high-vacuum rectification production workshop and 5,000-ton climate-controlled solid-chemical storage warehouse, guarantee 7-day fast delivery for full container orders, effectively avoid shipment-delay risk in peak-demand seasons.

1. Dual-Grade Strict Quality Control System
   Independent full-function laboratory equipped with gas chromatograph, Karl-Fischer moisture tester, melting-point apparatus and HPLC. Every batch undergoes full-index inspection before delivery, separate COA report issued for each batch to ensure stable purity and low-impurity fluctuation, no caking or discoloration under sealed storage.

1. Complete Global Export Qualifications
   Free provision of full-set export-clearance documents: COA, GHS English SDS, commercial invoice, packing list, certificate of origin, transport appraisal, packaging certificate, support customs clearance for ports of Europe, America, Southeast Asia, Middle East and Latin America. Our product complies with TSCA, REACH, IECSC and global major chemical-registration standards.

1. Flexible Tiered Quotation Policy

• Preferential bulk unit price for full 20GP / 40HQ containers;

• Extra discount for 100% T/T advance payment;

• Annual-framework-agreement price-lock policy for long-term fixed purchasers to hedge raw-material-price-fluctuation losses.

1. Professional One-Stop Export Service
   Specialized chemical foreign-trade team handles trailer, customs declaration, maritime booking and full-logistics tracking; customers only need to wait for cargo arrival at destination port without complicated export formalities.

6. Storage, Transportation & Safety Instructions

1. Storage: Store in dedicated cool, dry, ventilated chemical warehouse, strictly keep away from open flame, high-temperature heat source, strong oxidants, strong reducing agents, strong acids and strong bases; container must be fully sealed with moisture-proof inner liner to prevent moisture absorption and caking, storage temperature controlled below 30 C, shelf life 24 months under intact sealed package.

1. Transportation: Organic chemical solid, must ship with standard export container, complete packaging certificate and shipping document; avoid direct sunlight, rain and violent collision during loading & unloading, strictly separate from oxidizer and food cargo.

1. Safety Operation: Operators must wear chemical-resistant gloves, safety goggles and dust respirator; if dust contacts skin or eyes, rinse with massive clean water continuously for 15 minutes and seek medical treatment immediately; avoid inhalation of dust and prolonged skin contact. Full-English SDS details all fire-fighting, leakage-disposal and emergency-first-aid measures for overseas-warehouse management.

7. After-Sales Cooperation Guarantee

1. Batch Quality Traceability: We reserve sealed samples of each production batch for 6 months, support third-party independent re-inspection if customers raise quality doubts after goods arrival.

1. Quality-Problem Solution Mechanism: If test indexes fail to meet agreed standard, we support free re-delivery, proportional price deduction or economic compensation according to actual customer loss.

1. Long-Term Cooperative Client Priority Policy: Annual-framework customers enjoy priority-production scheduling, free lab-sample supply and one-to-one fine-chemical engineer technical-matching support.

1. Free Professional Technical Support: Our pyridine-derivative engineer team provides lifelong free technical consultation on 3-Cyanopyridine dosing proportion, moisture-proof storage method and downstream hydrolysis / hydrogenation synthesis-process optimization for all cooperative customers.